Abstract :C. albicans has the ability to form biofilms on biotic and abiotic surfaces. Biofilms are highly
resistant to various antifungal drugs and there are complex mechanisms underlying biofilm
resistance. Biofilm associated infections are urgently needed successful treatment. It has become
essential to develop alternative strategies in order to overcome the limitations of current antifungal
therapy against biofilm associated fungal infections. Developing new therapeutic approaches for
anti-biofilm activities, there is a need to find novel drugs from natural sources. Combination
therapies and exploring natural compounds and immune therapies are good approach to overcome
this problem. In addition to the discovery of new antifungal drugs, vaccines, antibiotics, natural
products, small molecules and synthesized compound are the important alternatives to be used
alone or in combination with antifungal drugs. Combination of molecules with different drugs is an
excellent strategy due to advantages of combination therapy like reduced side effects and reducing
the concentration of dosages of individual drugs and reduced toxicity.